General Information of the Compound
Compound ID
CP0520953
Compound Name
5-(6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yloxy)-N-[5-(1-hydroxy-2-methylpropan-2-yl)-1,2-oxazol-3-yl]indole-1-carboxamide
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Structure
Formula
C22H22N6O4
Molecular Weight
434.456
Canonical SMILES
CC(C)(CO)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5CNCc45)ccc23)no1
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InChI
InChI=1S/C22H22N6O4/c1-22(2,11-29)18-8-19(27-32-18)26-21(30)28-6-5-13-7-14(3-4-17(13)28)31-20-15-9-23-10-16(15)24-12-25-20/h3-8,12,23,29H,9-11H2,1-2H3,(H,26,27,30)
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InChIKey
ZGAABDMRSZLIAU-UHFFFAOYSA-N
Physicochemical Property
logP
3.1649
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
127.33
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
9
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137650589
ChEMBL ID
CHEMBL4079136
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 2.5 nM
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