General Information of the Compound
Compound ID
CP0520497
Compound Name
N'-(3-bromo-4-fluorophenyl)-4-[2-[5-[2-(dimethylamino)ethyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]ethylamino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide
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Structure
Formula
C17H24BrFN8O4S
Molecular Weight
535.4
Canonical SMILES
CN(C)CCN1CCN(CCNc2nonc2\C(Nc2ccc(F)c(Br)c2)=N\O)S1(=O)=O
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InChI
InChI=1S/C17H24BrFN8O4S/c1-25(2)7-8-27-10-9-26(32(27,29)30)6-5-20-16-15(23-31-24-16)17(22-28)21-12-3-4-14(19)13(18)11-12/h3-4,11,28H,5-10H2,1-2H3,(H,20,24)(H,21,22)
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InChIKey
UOARXWGUGPMRED-UHFFFAOYSA-N
Physicochemical Property
logP
1.055
Rotatable Bonds
9
Heavy Atom Count
32
Polar Areas
139.43
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
9
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155514212
ChEMBL ID
CHEMBL4439757
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01557, Indoleamine 2,3-dioxygenase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 45.7 nM
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