General Information of the Compound
Compound ID
CP0519806
Compound Name
(2S)-2-[(6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-4-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]-1-(4-piperidin-1-ylpiperidin-1-yl)butane-1,4-dione
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Structure
Formula
C32H41ClN10O3
Molecular Weight
649.2
Canonical SMILES
Clc1nc(N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)c2c[nH]nc2n1
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InChI
InChI=1S/C32H41ClN10O3/c33-31-37-28(24-19-34-39-29(24)38-31)35-26(30(45)42-16-8-22(9-17-42)40-12-4-1-5-13-40)18-27(44)41-14-10-23(11-15-41)43-20-21-6-2-3-7-25(21)36-32(43)46/h2-3,6-7,19,22-23,26H,1,4-5,8-18,20H2,(H,36,46)(H2,34,35,37,38,39)/t26-/m0/s1
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InChIKey
HJEUHGRWMSSEQS-SANMLTNESA-N
Physicochemical Property
logP
3.6925
Rotatable Bonds
7
Heavy Atom Count
46
Polar Areas
142.69
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 70693851
ChEMBL ID
CHEMBL2018495
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
IC50 = 99 nM
   TI
   LI
   LO
   TS
2
IC50 = 250 nM
   TI
   LI
   LO
   TS