General Information of the Compound
Compound ID
CP0519243
Compound Name
17beta-Hydroxy-11beta-[4-(1-methyl-6,9-dioxo-1-aza-5,10-dioxa-undecyl)-phenyl]-17alpha-(1-propinyl)-estra-4,9-dien-3-one
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Structure
Formula
C36H45NO6
Molecular Weight
587.757
Canonical SMILES
COC(=O)CCC(=O)OCCCN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
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InChI
InChI=1S/C36H45NO6/c1-5-18-36(41)19-17-31-29-13-9-25-22-27(38)12-14-28(25)34(29)30(23-35(31,36)2)24-7-10-26(11-8-24)37(3)20-6-21-43-33(40)16-15-32(39)42-4/h7-8,10-11,22,29-31,41H,6,9,12-17,19-21,23H2,1-4H3/t29-,30+,31-,35-,36-/m0/s1
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InChIKey
XHECBCVOTRJJPI-CGWUTTPTSA-N
Physicochemical Property
logP
5.6632
Rotatable Bonds
9
Heavy Atom Count
43
Polar Areas
93.14
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25231980
SID: 57583932
ChEMBL ID
CHEMBL506443
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 1.2 nM
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