General Information of the Compound
Compound ID
CP0518984
Compound Name
3-[2-(3-chlorophenyl)ethyl]-7-piperazin-1-yl-2-propan-2-ylimidazo[4,5-b]pyridine
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Structure
Formula
C21H26ClN5
Molecular Weight
383.927
Canonical SMILES
CC(C)c1nc2c(ccnc2n1CCc1cccc(Cl)c1)N1CCNCC1
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InChI
InChI=1S/C21H26ClN5/c1-15(2)20-25-19-18(26-12-9-23-10-13-26)6-8-24-21(19)27(20)11-7-16-4-3-5-17(22)14-16/h3-6,8,14-15,23H,7,9-13H2,1-2H3
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InChIKey
LFVPNNRGWXXMPD-UHFFFAOYSA-N
Physicochemical Property
logP
3.8604
Rotatable Bonds
5
Heavy Atom Count
27
Polar Areas
45.98
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145949620
ChEMBL ID
CHEMBL4171417
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 80 nM
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