General Information of the Compound
Compound ID
CP0518117
Compound Name
N-[1-[3-[4-(benzenesulfonamido)phenyl]-3-phenylpropyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
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Structure
Formula
C37H43N3O5S2
Molecular Weight
673.901
Canonical SMILES
CCN(C1CCN(CCC(c2ccccc2)c2ccc(NS(=O)(=O)c3ccccc3)cc2)CC1)C(=O)Cc1ccc(cc1)S(C)(=O)=O
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InChI
InChI=1S/C37H43N3O5S2/c1-3-40(37(41)28-29-14-20-34(21-15-29)46(2,42)43)33-22-25-39(26-23-33)27-24-36(30-10-6-4-7-11-30)31-16-18-32(19-17-31)38-47(44,45)35-12-8-5-9-13-35/h4-21,33,36,38H,3,22-28H2,1-2H3
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InChIKey
RMBIIDOEEPBEST-UHFFFAOYSA-N
Physicochemical Property
logP
5.9685
Rotatable Bonds
13
Heavy Atom Count
47
Polar Areas
103.86
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44404645
ChEMBL ID
CHEMBL198884
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 740 nM
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