General Information of the Compound
Compound ID
CP0517505
Compound Name
N-[2-(7-methyl-1H-indazol-5-yl)-1-pyridin-2-ylethyl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide
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Structure
Formula
C29H31N7O2
Molecular Weight
509.614
Canonical SMILES
Cc1cc(CC(NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)c2ccccn2)cc2cn[nH]c12
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InChI
InChI=1S/C29H31N7O2/c1-19-14-20(15-22-17-31-34-27(19)22)16-26(25-8-4-5-11-30-25)33-28(37)35-12-9-23(10-13-35)36-18-21-6-2-3-7-24(21)32-29(36)38/h2-8,11,14-15,17,23,26H,9-10,12-13,16,18H2,1H3,(H,31,34)(H,32,38)(H,33,37)
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InChIKey
HYLCZFDYURFPAG-UHFFFAOYSA-N
Physicochemical Property
logP
4.77182
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
106.25
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11295168
SID: 16382834
ChEMBL ID
CHEMBL2024592
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01670, Calcitonin gene-related peptide type 1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
IC50 = 3.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 4.1 nM
   TI
   LI
   LO
   TS