General Information of the Compound
Compound ID
CP0517019
Compound Name
4-[1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]indol-3-yl]butanoic acid
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Formula
C27H35N3O3
Molecular Weight
449.595
Canonical SMILES
COc1ccccc1N1CCN(CCCCn2cc(CCCC(O)=O)c3ccccc23)CC1
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InChI
InChI=1S/C27H35N3O3/c1-33-26-13-5-4-12-25(26)29-19-17-28(18-20-29)15-6-7-16-30-21-22(9-8-14-27(31)32)23-10-2-3-11-24(23)30/h2-5,10-13,21H,6-9,14-20H2,1H3,(H,31,32)
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InChIKey
YZCQTZCKJQJPLF-UHFFFAOYSA-N
Physicochemical Property
logP
4.6596
Rotatable Bonds
11
Heavy Atom Count
33
Polar Areas
57.94
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4792905
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01089, Alpha-1A adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 20.8 nM
   TI
   LI
   LO
   TS
Protein ID: PT01007, Alpha-1B adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01004, Alpha-1D adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 189 nM
   TI
   LI
   LO
   TS