General Information of the Compound
Compound ID
CP0516449
Compound Name
1-allyl-1-((1R,3S,5S)-8-(((3S,4R)-1-(cyclopentanecarbonyl)-4-(3-fluorophenyl)-4-hydroxypyrrolidin-3-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(4-fluorobenzyl)urea
    Show/Hide
Formula
C35H44F2N4O3
Molecular Weight
606.758
Canonical SMILES
O[C@@]1(CN(C[C@@H]1CN1[C@H]2CC[C@@H]1C[C@@H](C2)N(CC=C)C(=O)NCc1ccc(F)cc1)C(=O)C1CCCC1)c1cccc(F)c1
    Show/Hide
InChI
InChI=1S/C35H44F2N4O3/c1-2-16-40(34(43)38-20-24-10-12-28(36)13-11-24)32-18-30-14-15-31(19-32)41(30)22-27-21-39(33(42)25-6-3-4-7-25)23-35(27,44)26-8-5-9-29(37)17-26/h2,5,8-13,17,25,27,30-32,44H,1,3-4,6-7,14-16,18-23H2,(H,38,43)/t27-,30-,31+,32+,35+/m1/s1
    Show/Hide
InChIKey
JGKFTLRIOJCQTP-SDUKJWIDSA-N
Physicochemical Property
logP
5.1942
Rotatable Bonds
9
Heavy Atom Count
44
Polar Areas
76.12
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
ChEMBL ID
CHEMBL1222774
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS