General Information of the Compound
Compound ID
CP0516448
Compound Name
4-nitrobenzyl allyl(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-(3-fluorophenyl)-4-hydroxypyrrolidin-3-yl)methyl)piperidin-4-yl)carbamate
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Structure
Formula
C33H41FN4O6
Molecular Weight
608.711
Canonical SMILES
O[C@@]1(CN(C[C@@H]1CN1CCC(CC1)N(CC=C)C(=O)OCc1ccc(cc1)[N+]([O-])=O)C(=O)C1CCCC1)c1cccc(F)c1
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InChI
InChI=1S/C33H41FN4O6/c1-2-16-37(32(40)44-22-24-10-12-30(13-11-24)38(42)43)29-14-17-35(18-15-29)20-27-21-36(31(39)25-6-3-4-7-25)23-33(27,41)26-8-5-9-28(34)19-26/h2,5,8-13,19,25,27,29,41H,1,3-4,6-7,14-18,20-23H2/t27-,33-/m0/s1
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InChIKey
RGZRUHNOAFJLNC-CMVGPNDKSA-N
Physicochemical Property
logP
4.8593
Rotatable Bonds
10
Heavy Atom Count
44
Polar Areas
116.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49864969
ChEMBL ID
CHEMBL1222767
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 8.85 nM
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