General Information of the Compound
Compound ID
CP0516125
Compound Name
5-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methyl-thiophene-2-carbonitrile
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Structure
Formula
C16H14N2OS
Molecular Weight
282.368
Canonical SMILES
Cc1cc(sc1-c1ccc2NC(=O)C(C)(C)c2c1)C#N
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InChI
InChI=1S/C16H14N2OS/c1-9-6-11(8-17)20-14(9)10-4-5-13-12(7-10)16(2,3)15(19)18-13/h4-7H,1-3H3,(H,18,19)
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InChIKey
NIOCARGZGKGNDA-UHFFFAOYSA-N
Physicochemical Property
logP
3.8249
Rotatable Bonds
1
Heavy Atom Count
20
Polar Areas
52.89
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 21986241
ChEMBL ID
CHEMBL326955
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 29 nM
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