General Information of the Compound
Compound ID
CP0515170
Compound Name
3-(1,3-benzodioxol-5-ylmethyl)-8-[3,5-bis(trifluoromethyl)benzoyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione
    Show/Hide
Structure
Formula
C24H19F6N3O5
Molecular Weight
543.42
Canonical SMILES
FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCC2(CC1)NC(=O)N(Cc1ccc3OCOc3c1)C2=O
    Show/Hide
InChI
InChI=1S/C24H19F6N3O5/c25-23(26,27)15-8-14(9-16(10-15)24(28,29)30)19(34)32-5-3-22(4-6-32)20(35)33(21(36)31-22)11-13-1-2-17-18(7-13)38-12-37-17/h1-2,7-10H,3-6,11-12H2,(H,31,36)
    Show/Hide
InChIKey
GPTRXOXLGBUYRR-UHFFFAOYSA-N
Physicochemical Property
logP
4.1797
Rotatable Bonds
3
Heavy Atom Count
38
Polar Areas
88.18
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44318269
ChEMBL ID
CHEMBL84761
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 245.47 nM
   TI
   LI
   LO
   TS