General Information of the Compound
Compound ID
CP0515112
Compound Name
1-(4-((3S,4R)-3-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)pyrrolidine-1-carbonyl)piperazin-1-yl)ethanone
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Structure
Formula
C27H28F7N3O3
Molecular Weight
575.525
Canonical SMILES
C[C@@H](O[C@@H]1CN(C[C@H]1c1ccc(F)cc1)C(=O)N1CCN(CC1)C(C)=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
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InChI
InChI=1S/C27H28F7N3O3/c1-16(19-11-20(26(29,30)31)13-21(12-19)27(32,33)34)40-24-15-37(14-23(24)18-3-5-22(28)6-4-18)25(39)36-9-7-35(8-10-36)17(2)38/h3-6,11-13,16,23-24H,7-10,14-15H2,1-2H3/t16-,23+,24-/m1/s1
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InChIKey
NBMRLKJWYTZCGO-QQTNTEGQSA-N
Physicochemical Property
logP
5.693
Rotatable Bonds
4
Heavy Atom Count
40
Polar Areas
53.09
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44444671
ChEMBL ID
CHEMBL400060
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.3 nM
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