General Information of the Compound
Compound ID
CP0512726
Compound Name
N-(2-phenyl-2-piperidin-1-ylethyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
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Structure
Formula
C30H34N6O2
Molecular Weight
510.642
Canonical SMILES
O=C(NCC(N1CCCCC1)c1ccccc1)N1CCC(CC1)c1nc(no1)-c1ccc2ccccc2n1
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InChI
InChI=1S/C30H34N6O2/c37-30(31-21-27(23-10-3-1-4-11-23)35-17-7-2-8-18-35)36-19-15-24(16-20-36)29-33-28(34-38-29)26-14-13-22-9-5-6-12-25(22)32-26/h1,3-6,9-14,24,27H,2,7-8,15-21H2,(H,31,37)
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InChIKey
AWUSEWFIOJHHGJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.401
Rotatable Bonds
6
Heavy Atom Count
38
Polar Areas
87.39
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56664980
ChEMBL ID
CHEMBL1822453
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
2
IC50 = 330 nM
   TI
   LI
   LO
   TS