General Information of the Compound
Compound ID
CP0511779
Compound Name
N-[2-(4-chlorophenyl)ethyl]-N-(1,4-dioxaspiro[4.5]decan-8-yl)-2-propan-2-yloxypyridine-3-carboxamide
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Structure
Formula
C25H31ClN2O4
Molecular Weight
458.986
Canonical SMILES
CC(C)Oc1ncccc1C(=O)N(CCc1ccc(Cl)cc1)C1CCC2(CC1)OCCO2
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InChI
InChI=1S/C25H31ClN2O4/c1-18(2)32-23-22(4-3-14-27-23)24(29)28(15-11-19-5-7-20(26)8-6-19)21-9-12-25(13-10-21)30-16-17-31-25/h3-8,14,18,21H,9-13,15-17H2,1-2H3
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InChIKey
KKAPTAWCJOYXKJ-UHFFFAOYSA-N
Physicochemical Property
logP
4.8928
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
60.89
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44589817
ChEMBL ID
CHEMBL520381
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02772, C5a anaphylatoxin chemotactic receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 835 nM
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