General Information of the Compound
Compound ID
CP0511341
Compound Name
1-(4-Isopropyl benzenesulfonyl)-5-(piperazin-1-yl-methyl)-1H-indole
    Show/Hide
Structure
Formula
C22H27N3O2S
Molecular Weight
397.544
Canonical SMILES
CC(C)c1ccc(cc1)S(=O)(=O)n1ccc2cc(CN3CCNCC3)ccc12
    Show/Hide
InChI
InChI=1S/C22H27N3O2S/c1-17(2)19-4-6-21(7-5-19)28(26,27)25-12-9-20-15-18(3-8-22(20)25)16-24-13-10-23-11-14-24/h3-9,12,15,17,23H,10-11,13-14,16H2,1-2H3
    Show/Hide
InChIKey
ZCLMNAOXIFZSNT-UHFFFAOYSA-N
Physicochemical Property
logP
3.4069
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
54.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 25025118
ChEMBL ID
CHEMBL1785069
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 14.9 nM
   TI
   LI
   LO
   TS