General Information of the Compound
Compound ID
CP0509116
Compound Name
(2S,3S)-N-[[5-(5-ethyltetrazol-1-yl)-2-methoxyphenyl]methyl]-2-phenylpiperidin-3-amine;dihydrochloride
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Structure
Formula
C22H30Cl2N6O
Molecular Weight
465.429
Canonical SMILES
Cl.Cl.CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1
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InChI
InChI=1S/C22H28N6O.2ClH/c1-3-21-25-26-27-28(21)18-11-12-20(29-2)17(14-18)15-24-19-10-7-13-23-22(19)16-8-5-4-6-9-16;;/h4-6,8-9,11-12,14,19,22-24H,3,7,10,13,15H2,1-2H3;2*1H/t19-,22-;;/m0../s1
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InChIKey
UJTIPVXREXIGKW-VVJLZRNGSA-N
Physicochemical Property
logP
3.6598
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
76.89
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45259228
ChEMBL ID
CHEMBL545360
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.05012 nM
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