General Information of the Compound
Compound ID
CP0507826
Compound Name
(S)-2-((4R,5R)-5-(biphenyl-2-ylcarbamoyl)-1,3-dioxolane-4-carboxamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid
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Structure
Formula
C33H27Cl2N3O7
Molecular Weight
648.499
Canonical SMILES
OC(=O)[C@H](Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1)NC(=O)[C@@H]1OCO[C@H]1C(=O)Nc1ccccc1-c1ccccc1
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InChI
InChI=1S/C33H27Cl2N3O7/c34-23-10-6-11-24(35)27(23)30(39)36-21-15-13-19(14-16-21)17-26(33(42)43)38-32(41)29-28(44-18-45-29)31(40)37-25-12-5-4-9-22(25)20-7-2-1-3-8-20/h1-16,26,28-29H,17-18H2,(H,36,39)(H,37,40)(H,38,41)(H,42,43)/t26-,28+,29+/m0/s1
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InChIKey
GKVFPAULNAWNJX-WIIGKZCBSA-N
Physicochemical Property
logP
5.4048
Rotatable Bonds
10
Heavy Atom Count
45
Polar Areas
143.06
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49865759
ChEMBL ID
CHEMBL1223921
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01186, Integrin alpha-4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 100 nM
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