General Information of the Compound
Compound ID
CP0507523
Compound Name
3-(4-isopropylphenylsulfonyl)-N-(3-methoxyphenyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
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Structure
Formula
C23H21N5O3S2
Molecular Weight
479.587
Canonical SMILES
COc1cccc(Nc2nc3c(nnn3c3ccsc23)S(=O)(=O)c2ccc(cc2)C(C)C)c1
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InChI
InChI=1S/C23H21N5O3S2/c1-14(2)15-7-9-18(10-8-15)33(29,30)23-22-25-21(24-16-5-4-6-17(13-16)31-3)20-19(11-12-32-20)28(22)27-26-23/h4-14H,1-3H3,(H,24,25)
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InChIKey
QQRYJPQWFTYNDK-UHFFFAOYSA-N
Physicochemical Property
logP
5.0474
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
98.48
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 18559353
ChEMBL ID
CHEMBL1170288
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 900 nM
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