General Information of the Compound
Compound ID
CP0506148
Compound Name
(5S)-7,9-difluoro-2,2,4-trimethyl-5-[(1R)-3-methylcyclohex-2-en-1-yl]-1,5-dihydrochromeno[3,4-f]quinoline
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Structure
Formula
C26H27F2NO
Molecular Weight
407.504
Canonical SMILES
CC1=C[C@@H](CCC1)[C@@H]1Oc2c(F)cc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
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InChI
InChI=1S/C26H27F2NO/c1-14-6-5-7-16(10-14)24-23-18(19-11-17(27)12-20(28)25(19)30-24)8-9-21-22(23)15(2)13-26(3,4)29-21/h8-13,16,24,29H,5-7H2,1-4H3/t16-,24+/m1/s1
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InChIKey
NNEGFNICKYKFDF-GYCJOSAFSA-N
Physicochemical Property
logP
7.4191
Rotatable Bonds
1
Heavy Atom Count
30
Polar Areas
21.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24895095
SID: 53779286
ChEMBL ID
CHEMBL510373
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
EC50 = 33 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 14 nM