General Information of the Compound
Compound ID
CP0506104
Compound Name
1-{1-[3-(3-Isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-3-thiazol-2-yl-urea
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Structure
Formula
C25H28N6O3S
Molecular Weight
492.605
Canonical SMILES
CC(C)NC(=O)Nc1cccc(CN2c3ccccc3CCC(NC(=O)Nc3nccs3)C2=O)c1
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InChI
InChI=1S/C25H28N6O3S/c1-16(2)27-23(33)28-19-8-5-6-17(14-19)15-31-21-9-4-3-7-18(21)10-11-20(22(31)32)29-24(34)30-25-26-12-13-35-25/h3-9,12-14,16,20H,10-11,15H2,1-2H3,(H2,27,28,33)(H2,26,29,30,34)
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InChIKey
VVZDLSQBFMXHTG-UHFFFAOYSA-N
Physicochemical Property
logP
4.3427
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
115.46
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10505296
SID: 15530302
ChEMBL ID
CHEMBL88450
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02259, Neuropeptide Y receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 160 nM
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   LI
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