General Information of the Compound
Compound ID
CP0504593
Compound Name
5-((3aR,6aS)-5-((S)-5-butyl-2-oxo-3-((tetrahydro-2H-pyran-4-yl)methyl)-1-oxa-3,9-diazaspiro[5.5]undecan-9-yl)octahydrocyclopenta[c]pyrrole-2-carbonyl)-4,6-dimethylpicolinonitrile
    Show/Hide
Structure
Formula
C34H49N5O4
Molecular Weight
591.797
Canonical SMILES
CCCC[C@H]1CN(CC2CCOCC2)C(=O)OC11CCN(CC1)C1C[C@H]2CN(C[C@H]2C1)C(=O)c1c(C)cc(nc1C)C#N
    Show/Hide
InChI
InChI=1S/C34H49N5O4/c1-4-5-6-28-22-39(19-25-7-13-42-14-8-25)33(41)43-34(28)9-11-37(12-10-34)30-16-26-20-38(21-27(26)17-30)32(40)31-23(2)15-29(18-35)36-24(31)3/h15,25-28,30H,4-14,16-17,19-22H2,1-3H3/t26-,27+,28-,30?/m0/s1
    Show/Hide
InChIKey
ZBPKKPLEISFHIZ-QTJAHOOZSA-N
Physicochemical Property
logP
4.94052
Rotatable Bonds
7
Heavy Atom Count
43
Polar Areas
99
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 46882077
ChEMBL ID
CHEMBL1077359
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS