General Information of the Compound
Compound ID
CP0504475
Compound Name
3-(2,5-dimethylphenylsulfonyl)-5-(1-methylpiperidin-4-yl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine
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Structure
Formula
C21H23N5O2S2
Molecular Weight
441.582
Canonical SMILES
CN1CCC(CC1)c1nc2c(nnn2c2ccsc12)S(=O)(=O)c1cc(C)ccc1C
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InChI
InChI=1S/C21H23N5O2S2/c1-13-4-5-14(2)17(12-13)30(27,28)21-20-22-18(15-6-9-25(3)10-7-15)19-16(8-11-29-19)26(20)24-23-21/h4-5,8,11-12,15H,6-7,9-10H2,1-3H3
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InChIKey
RLYQIEILBIMMSQ-UHFFFAOYSA-N
Physicochemical Property
logP
3.59784
Rotatable Bonds
3
Heavy Atom Count
30
Polar Areas
80.46
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49799664
ChEMBL ID
CHEMBL1173774
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1340 nM
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