General Information of the Compound
Compound ID
CP0504464
Compound Name
3-(3,4-dimethylphenylsulfonyl)-N-(1-phenylpropan-2-yl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
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Structure
Formula
C24H23N5O2S2
Molecular Weight
477.615
Canonical SMILES
CC(Cc1ccccc1)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1ccc(C)c(C)c1
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InChI
InChI=1S/C24H23N5O2S2/c1-15-9-10-19(13-16(15)2)33(30,31)24-23-26-22(21-20(11-12-32-21)29(23)28-27-24)25-17(3)14-18-7-5-4-6-8-18/h4-13,17H,14H2,1-3H3,(H,25,26)
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InChIKey
CVCSNDQLVPCGPD-UHFFFAOYSA-N
Physicochemical Property
logP
4.83174
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
89.25
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 18560324
ChEMBL ID
CHEMBL1170890
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 680 nM
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