General Information of the Compound
Compound ID
CP0503236
Compound Name
2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide
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Structure
Formula
C34H21F6N3O3
Molecular Weight
633.548
Canonical SMILES
FC(F)(F)c1cc(CNC(=O)c2c(CN3C(=O)c4ccccc4C3=O)nc3ccccc3c2-c2ccccc2)cc(c1)C(F)(F)F
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InChI
InChI=1S/C34H21F6N3O3/c35-33(36,37)21-14-19(15-22(16-21)34(38,39)40)17-41-30(44)29-27(18-43-31(45)23-10-4-5-11-24(23)32(43)46)42-26-13-7-6-12-25(26)28(29)20-8-2-1-3-9-20/h1-16H,17-18H2,(H,41,44)
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InChIKey
TZBLHTJIWAJSOK-UHFFFAOYSA-N
Physicochemical Property
logP
7.6656
Rotatable Bonds
6
Heavy Atom Count
46
Polar Areas
79.37
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11399458
SID: 16494308
ChEMBL ID
CHEMBL25058
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000441 UC-11MG Homo sapiens (Human)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS