General Information of the Compound
Compound ID
CP0502996
Compound Name
17beta-Hydroxy-11beta-[4-(7-methoxycarbonyl-N-methylheptylamino)-phenyl]-17alpha-(1-propinyl)-estra-4,9-dien-3-one
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Structure
Formula
C37H49NO4
Molecular Weight
571.802
Canonical SMILES
COC(=O)CCCCCCCN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
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InChI
InChI=1S/C37H49NO4/c1-5-21-37(41)22-20-33-31-18-14-27-24-29(39)17-19-30(27)35(31)32(25-36(33,37)2)26-12-15-28(16-13-26)38(3)23-10-8-6-7-9-11-34(40)42-4/h12-13,15-16,24,31-33,41H,6-11,14,17-20,22-23,25H2,1-4H3/t31-,32+,33-,36-,37-/m0/s1
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InChIKey
UFPWBOJPIGVROU-MYOLODFCSA-N
Physicochemical Property
logP
7.2903
Rotatable Bonds
10
Heavy Atom Count
42
Polar Areas
66.84
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25233573
SID: 57585533
ChEMBL ID
CHEMBL499452
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 0.47 nM
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