General Information of the Compound
Compound ID
CP0502369
Compound Name
2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]adamantane-2-carboxylic acid
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Synonyms
CHEMBL507382
H-Arg-Arg-Pro-Tyr-Ile-Aac-OH
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Structure
Formula
C43H68N12O8
Molecular Weight
881.093
Canonical SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O
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InChI
InChI=1S/C43H68N12O8/c1-3-23(2)34(38(60)54-43(40(62)63)27-18-25-17-26(20-27)21-28(43)19-25)53-36(58)32(22-24-10-12-29(56)13-11-24)52-37(59)33-9-6-16-55(33)39(61)31(8-5-15-50-42(47)48)51-35(57)30(44)7-4-14-49-41(45)46/h10-13,23,25-28,30-34,56H,3-9,14-22,44H2,1-2H3,(H,51,57)(H,52,59)(H,53,58)(H,54,60)(H,62,63)(H4,45,46,49)(H4,47,48,50)/t23-,25?,26?,27?,28?,30-,31-,32-,33-,34-,43?/m0/s1
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InChIKey
CMCIRTPGPAKLJS-YTNDVNQYSA-N
Physicochemical Property
logP
-0.7436
Rotatable Bonds
22
Heavy Atom Count
63
Polar Areas
349.06
Hydrogen Bond Donor Count
11
Hydrogen Bond Acceptor Count
10
Complexity
63

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44578945
ChEMBL ID
CHEMBL507382
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02429, Neurotensin receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 2.4 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( H-Arg-Arg-Pro-Tyr-Ile-Aac-OH )
Drug Name H-Arg-Arg-Pro-Tyr-Ile-Aac-OH
Target(s)
Neurotensin receptor type 1 (NTSR1)
Inhibitor