General Information of the Compound
Compound ID
CP0500893
Compound Name
5-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1'-methylsulfonyl-2-(naphthalene-2-carbonyl)spiro[3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrrole-3,4'-piperidine]-4,6-dione
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Structure
Formula
C31H27F6N3O5S
Molecular Weight
667.628
Canonical SMILES
CS(=O)(=O)N1CCC2(CC1)C1C(CN2C(=O)c2ccc3ccccc3c2)C(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C1=O
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InChI
InChI=1S/C31H27F6N3O5S/c1-46(44,45)38-10-8-29(9-11-38)25-24(17-40(29)26(41)21-7-6-19-4-2-3-5-20(19)14-21)27(42)39(28(25)43)16-18-12-22(30(32,33)34)15-23(13-18)31(35,36)37/h2-7,12-15,24-25H,8-11,16-17H2,1H3
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InChIKey
UGULBQBVNWXBKM-UHFFFAOYSA-N
Physicochemical Property
logP
4.9288
Rotatable Bonds
4
Heavy Atom Count
46
Polar Areas
95.07
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44334591
ChEMBL ID
CHEMBL318093
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 263.03 nM
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   LI
   LO
   TS