General Information of the Compound
Compound ID
CP0499186
Compound Name
N-[(1-piperidin-1-ylcyclopentyl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperazine-1-carboxamide
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Structure
Formula
C27H35N7O2
Molecular Weight
489.624
Canonical SMILES
O=C(NCC1(CCCC1)N1CCCCC1)N1CCN(CC1)c1nc(no1)-c1ccc2ccccc2n1
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InChI
InChI=1S/C27H35N7O2/c35-25(28-20-27(12-4-5-13-27)34-14-6-1-7-15-34)32-16-18-33(19-17-32)26-30-24(31-36-26)23-11-10-21-8-2-3-9-22(21)29-23/h2-3,8-11H,1,4-7,12-20H2,(H,28,35)
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InChIKey
FCASSQSBMNODOO-UHFFFAOYSA-N
Physicochemical Property
logP
3.9151
Rotatable Bonds
5
Heavy Atom Count
36
Polar Areas
90.63
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56671929
ChEMBL ID
CHEMBL1822466
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
2
IC50 = 10 nM
   TI
   LI
   LO
   TS