General Information of the Compound
Compound ID
CP0499097
Compound Name
N-[(1-ethylpyrrolidin-2-yl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
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Structure
Formula
C24H30N6O2
Molecular Weight
434.544
Canonical SMILES
CCN1CCCC1CNC(=O)N1CCC(CC1)c1nc(no1)-c1ccc2ccccc2n1
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InChI
InChI=1S/C24H30N6O2/c1-2-29-13-5-7-19(29)16-25-24(31)30-14-11-18(12-15-30)23-27-22(28-32-23)21-10-9-17-6-3-4-8-20(17)26-21/h3-4,6,8-10,18-19H,2,5,7,11-16H2,1H3,(H,25,31)
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InChIKey
CTVXXXLPYWOUHW-UHFFFAOYSA-N
Physicochemical Property
logP
3.6581
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
87.39
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56675307
ChEMBL ID
CHEMBL1822457
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
2
IC50 = 490 nM
   TI
   LI
   LO
   TS