General Information of the Compound
Compound ID
CP0498588
Compound Name
CHEMBL1081477
    Show/Hide
Formula
C26H36FN5O2
Molecular Weight
469.605
Canonical SMILES
Cc1nnc(C)n1[C@@H]1C[C@H]2CN(CC[C@H](NC(=O)C3CCOCC3)c3cccc(F)c3)C[C@H]2C1
    Show/Hide
InChI
InChI=1S/C26H36FN5O2/c1-17-29-30-18(2)32(17)24-13-21-15-31(16-22(21)14-24)9-6-25(20-4-3-5-23(27)12-20)28-26(33)19-7-10-34-11-8-19/h3-5,12,19,21-22,24-25H,6-11,13-16H2,1-2H3,(H,28,33)/t21-,22+,24+,25-/m0/s1
    Show/Hide
InChIKey
WKSLSTLBQGAPKU-AICRDVKUSA-N
Physicochemical Property
logP
3.59114
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
72.28
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
ChEMBL ID
CHEMBL1081477
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 43 nM
   TI
   LI
   LO
   TS