General Information of the Compound
Compound ID
CP0498454
Compound Name
1'-[2-(3,4-dichlorophenylcarboxamido)-3-[3,5-di(trifluoromethyl)benzyloxy]-(2S)-propanoyl]-1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]
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Structure
Formula
C32H29Cl2F6N3O5S
Molecular Weight
752.561
Canonical SMILES
CS(=O)(=O)N1CC2(CCN(CC2)C(=O)[C@H](COCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)NC(=O)c2ccc(Cl)c(Cl)c2)c2ccccc12
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InChI
InChI=1S/C32H29Cl2F6N3O5S/c1-49(46,47)43-18-30(23-4-2-3-5-27(23)43)8-10-42(11-9-30)29(45)26(41-28(44)20-6-7-24(33)25(34)14-20)17-48-16-19-12-21(31(35,36)37)15-22(13-19)32(38,39)40/h2-7,12-15,26H,8-11,16-18H2,1H3,(H,41,44)/t26-/m0/s1
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InChIKey
UACCBGLNPJVHMU-SANMLTNESA-N
Physicochemical Property
logP
6.6862
Rotatable Bonds
8
Heavy Atom Count
49
Polar Areas
96.02
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
49

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44297728
ChEMBL ID
CHEMBL292874
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1300 nM
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