General Information of the Compound
Compound ID
CP0497156
Compound Name
(+/-)-4-[5-(4-Fluorophenyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]benzoic Acid
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Structure
Formula
C23H19FN2O3
Molecular Weight
390.414
Canonical SMILES
COc1ccc(cc1)N1N=C(CC1c1ccc(F)cc1)c1ccc(cc1)C(O)=O
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InChI
InChI=1S/C23H19FN2O3/c1-29-20-12-10-19(11-13-20)26-22(16-6-8-18(24)9-7-16)14-21(25-26)15-2-4-17(5-3-15)23(27)28/h2-13,22H,14H2,1H3,(H,27,28)
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InChIKey
HFIXZIZXNSWXRT-UHFFFAOYSA-N
Physicochemical Property
logP
4.8882
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
62.13
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46915031
SID: 99379589
ChEMBL ID
CHEMBL1214765
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01154, Mineralocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
IC50 = 1440 nM
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