General Information of the Compound
Compound ID
CP0497051
Compound Name
3-(3-Cyano-phenyl)-1-[1-(3,3-diphenyl-propyl)-piperidin-4-yl]-1-methyl-urea
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Structure
Formula
C29H32N4O
Molecular Weight
452.602
Canonical SMILES
CN(C1CCN(CCC(c2ccccc2)c2ccccc2)CC1)C(=O)Nc1cccc(c1)C#N
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InChI
InChI=1S/C29H32N4O/c1-32(29(34)31-26-14-8-9-23(21-26)22-30)27-15-18-33(19-16-27)20-17-28(24-10-4-2-5-11-24)25-12-6-3-7-13-25/h2-14,21,27-28H,15-20H2,1H3,(H,31,34)
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InChIKey
BBKRNDDRYCWYAA-UHFFFAOYSA-N
Physicochemical Property
logP
5.70858
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
59.37
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44392104
ChEMBL ID
CHEMBL425168
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 4900 nM
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