General Information of the Compound
Compound ID
CP0497033
Compound Name
5-(3-fluoro-5-methoxyphenyl)spiro[1H-indole-3,1'-cyclohexane]-2-thione
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Structure
Formula
C20H20FNOS
Molecular Weight
341.451
Canonical SMILES
COc1cc(F)cc(c1)-c1ccc2NC(=S)C3(CCCCC3)c2c1
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InChI
InChI=1S/C20H20FNOS/c1-23-16-10-14(9-15(21)12-16)13-5-6-18-17(11-13)20(19(24)22-18)7-3-2-4-8-20/h5-6,9-12H,2-4,7-8H2,1H3,(H,22,24)
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InChIKey
MLPXJNYJKQYTRC-UHFFFAOYSA-N
Physicochemical Property
logP
5.4561
Rotatable Bonds
2
Heavy Atom Count
24
Polar Areas
21.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10472499
SID: 15495970
ChEMBL ID
CHEMBL286029
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
EC50 = 2.6 nM
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