General Information of the Compound
Compound ID
CP0496746
Compound Name
(S)-Piperazine-1,2,4-tricarboxylic acid 2-({2-[(3,5-bis-trifluoromethyl-benzyl)-methyl-amino]-ethyl}-methyl-amide) 4-dipentylamide 1-diphenylamide
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Structure
Formula
C42H54F6N6O3
Molecular Weight
804.921
Canonical SMILES
CCCCCN(CCCCC)C(=O)N1CCN([C@@H](C1)C(=O)N(C)CCN(C)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)N(c1ccccc1)c1ccccc1
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InChI
InChI=1S/C42H54F6N6O3/c1-5-7-15-21-51(22-16-8-6-2)39(56)52-25-26-53(40(57)54(35-17-11-9-12-18-35)36-19-13-10-14-20-36)37(31-52)38(55)50(4)24-23-49(3)30-32-27-33(41(43,44)45)29-34(28-32)42(46,47)48/h9-14,17-20,27-29,37H,5-8,15-16,21-26,30-31H2,1-4H3/t37-/m0/s1
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InChIKey
RDKQAVZIXBHKDK-QNGWXLTQSA-N
Physicochemical Property
logP
9.3613
Rotatable Bonds
16
Heavy Atom Count
57
Polar Areas
70.65
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
57

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44324705
ChEMBL ID
CHEMBL329445
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1080 nM
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