General Information of the Compound
Compound ID
CP0496036
Compound Name
N'-[10-(3-chlorophenyl)sulfonyl-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaen-7-yl]-N,N,N'-trimethylethane-1,2-diamine
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Structure
Formula
C18H19ClN6O2S2
Molecular Weight
450.977
Canonical SMILES
CN(C)CCN(C)c1nc2c(nnn2c2ccsc12)S(=O)(=O)c1cccc(Cl)c1
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InChI
InChI=1S/C18H19ClN6O2S2/c1-23(2)8-9-24(3)16-15-14(7-10-28-15)25-17(20-16)18(21-22-25)29(26,27)13-6-4-5-12(19)11-13/h4-7,10-11H,8-9H2,1-3H3
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InChIKey
FWGIYGKLYGIQNP-UHFFFAOYSA-N
Physicochemical Property
logP
2.823
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
83.7
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49799656
ChEMBL ID
CHEMBL1173432
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 580 nM
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