General Information of the Compound
Compound ID
CP0495475
Compound Name
methyl 2-[(2S,3S)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]-2-oxoacetate
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Structure
Formula
C23H21F6NO4
Molecular Weight
489.412
Canonical SMILES
COC(=O)C(=O)N1CCC[C@H](OCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c1ccccc1
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InChI
InChI=1S/C23H21F6NO4/c1-33-21(32)20(31)30-9-5-8-18(19(30)15-6-3-2-4-7-15)34-13-14-10-16(22(24,25)26)12-17(11-14)23(27,28)29/h2-4,6-7,10-12,18-19H,5,8-9,13H2,1H3/t18-,19-/m0/s1
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InChIKey
RWCQGMYLKBMGOP-OALUTQOASA-N
Physicochemical Property
logP
5.1461
Rotatable Bonds
4
Heavy Atom Count
34
Polar Areas
55.84
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44307137
ChEMBL ID
CHEMBL302315
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 68 nM
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