General Information of the Compound
Compound ID
CP0494832
Compound Name
N-[(3S)-1-[2-(4-phenylbutyl)-1-benzofuran-4-yl]pyrrolidin-3-yl]acetamide
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Structure
Formula
C24H28N2O2
Molecular Weight
376.5
Canonical SMILES
CC(=O)N[C@H]1CCN(C1)c1cccc2oc(CCCCc3ccccc3)cc12
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InChI
InChI=1S/C24H28N2O2/c1-18(27)25-20-14-15-26(17-20)23-12-7-13-24-22(23)16-21(28-24)11-6-5-10-19-8-3-2-4-9-19/h2-4,7-9,12-13,16,20H,5-6,10-11,14-15,17H2,1H3,(H,25,27)/t20-/m0/s1
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InChIKey
ZPTOWOYNLSHOIH-FQEVSTJZSA-N
Physicochemical Property
logP
4.713
Rotatable Bonds
7
Heavy Atom Count
28
Polar Areas
45.48
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44394532
ChEMBL ID
CHEMBL188016
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01843, Melatonin receptor type 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
Ki = 22 nM
   TI
   LI
   LO
   TS
Protein ID: PT02174, Melatonin receptor type 1B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
Ki = 14 nM
   TI
   LI
   LO
   TS