General Information of the Compound
Compound ID
CP0494166
Compound Name
CHEMBL4853155
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Formula
C22H25ClN6O2
Molecular Weight
440.935
Canonical SMILES
CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2ccc(Cl)c(O)c2)c2c(N)ncnc12
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InChI
InChI=1S/C22H25ClN6O2/c1-13(30)27-4-6-28(7-5-27)15-9-16(10-15)29-11-17(14-2-3-18(23)19(31)8-14)20-21(24)25-12-26-22(20)29/h2-3,8,11-12,15-16,31H,4-7,9-10H2,1H3,(H2,24,25,26)/t15-,16+
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InChIKey
HLOASMXRJBZZAG-IYBDPMFKSA-N
Physicochemical Property
logP
2.9071
Rotatable Bonds
3
Heavy Atom Count
31
Polar Areas
100.51
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4853155
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 760 nM
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