General Information of the Compound
Compound ID
CP0493593
Compound Name
1-[3-(4-chlorophenyl)-3,4-dihydropyrazol-2-yl]-2,2-dimethylpropan-1-one
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Structure
Formula
C14H17ClN2O
Molecular Weight
264.756
Canonical SMILES
CC(C)(C)C(=O)N1N=CCC1c1ccc(Cl)cc1
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InChI
InChI=1S/C14H17ClN2O/c1-14(2,3)13(18)17-12(8-9-16-17)10-4-6-11(15)7-5-10/h4-7,9,12H,8H2,1-3H3
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InChIKey
IXHRJWLDAYBARM-UHFFFAOYSA-N
Physicochemical Property
logP
3.6453
Rotatable Bonds
1
Heavy Atom Count
18
Polar Areas
32.67
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
18

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122703656
ChEMBL ID
CHEMBL4576386
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00954, Receptor-interacting serine/threonine-protein kinase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 13 nM
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