General Information of the Compound
Compound ID
CP0492413
Compound Name
N-ethyl-2-(4-methylsulfonylphenyl)-N-[1-[(3R)-3-(3-methylsulfonylphenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]acetamide
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Structure
Formula
C32H47N3O7S3
Molecular Weight
681.943
Canonical SMILES
CCN(C1CCN(CC[C@H](C2CCN(CC2)S(C)(=O)=O)c2cccc(c2)S(C)(=O)=O)CC1)C(=O)Cc1ccc(cc1)S(C)(=O)=O
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InChI
InChI=1S/C32H47N3O7S3/c1-5-35(32(36)23-25-9-11-29(12-10-25)43(2,37)38)28-15-18-33(19-16-28)20-17-31(26-13-21-34(22-14-26)45(4,41)42)27-7-6-8-30(24-27)44(3,39)40/h6-12,24,26,28,31H,5,13-23H2,1-4H3/t31-/m1/s1
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InChIKey
POSCTKCOIKQVHU-WJOKGBTCSA-N
Physicochemical Property
logP
3.1945
Rotatable Bonds
12
Heavy Atom Count
45
Polar Areas
129.21
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57400375
ChEMBL ID
CHEMBL1951910
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 794 nM
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