General Information of the Compound
Compound ID
CP0492139
Compound Name
N-[[(1R,2R)-2-[2-(4-phenylbutyl)-1,3-benzoxazol-7-yl]cyclopropyl]methyl]acetamide
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Structure
Formula
C23H26N2O2
Molecular Weight
362.473
Canonical SMILES
CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12
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InChI
InChI=1S/C23H26N2O2/c1-16(26)24-15-18-14-20(18)19-11-7-12-21-23(19)27-22(25-21)13-6-5-10-17-8-3-2-4-9-17/h2-4,7-9,11-12,18,20H,5-6,10,13-15H2,1H3,(H,24,26)/t18-,20+/m0/s1
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InChIKey
YSLIKCKRXZNCIC-AZUAARDMSA-N
Physicochemical Property
logP
4.6328
Rotatable Bonds
8
Heavy Atom Count
27
Polar Areas
55.13
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9998754
SID: 14978349
ChEMBL ID
CHEMBL2112700
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01843, Melatonin receptor type 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
Ki = 0.05 nM
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   LI
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   TS
Protein ID: PT02174, Melatonin receptor type 1B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
Ki = 0.37 nM
   TI
   LI
   LO
   TS