General Information of the Compound
Compound ID
CP0491682
Compound Name
N'-hydroxy-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]heptanediamide
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Structure
Formula
C27H34N2O8
Molecular Weight
514.575
Canonical SMILES
COc1cc2CC[C@H](NC(=O)CCCCCC(=O)NO)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
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InChI
InChI=1S/C27H34N2O8/c1-34-21-13-11-17-18(15-20(21)30)19(28-23(31)8-6-5-7-9-24(32)29-33)12-10-16-14-22(35-2)26(36-3)27(37-4)25(16)17/h11,13-15,19,33H,5-10,12H2,1-4H3,(H,28,31)(H,29,32)/t19-/m0/s1
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InChIKey
CDDOIYGOWWHPGF-IBGZPJMESA-N
Physicochemical Property
logP
3.3076
Rotatable Bonds
11
Heavy Atom Count
37
Polar Areas
132.42
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71660262
ChEMBL ID
CHEMBL2385955
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00991, Histone deacetylase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
Protein ID: PT00995, Histone deacetylase 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 1030 nM
   TI
   LI
   LO
   TS
Protein ID: PT01213, Histone deacetylase 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 760 nM
   TI
   LI
   LO
   TS