General Information of the Compound
Compound ID
CP0490640
Compound Name
4-[6-[4-[1-[(3-chlorophenyl)methyl]indol-4-yl]piperazin-1-yl]hexoxy]-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
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Formula
C37H43ClN4O
Molecular Weight
595.231
Canonical SMILES
Clc1cccc(Cn2ccc3c(cccc23)N2CCN(CCCCCCOc3cccc4C(CCc34)NCC#C)CC2)c1
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InChI
InChI=1S/C37H43ClN4O/c1-2-19-39-34-17-16-32-31(34)12-8-15-37(32)43-26-6-4-3-5-20-40-22-24-41(25-23-40)35-13-9-14-36-33(35)18-21-42(36)28-29-10-7-11-30(38)27-29/h1,7-15,18,21,27,34,39H,3-6,16-17,19-20,22-26,28H2
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InChIKey
ISKBDJTZKOCFEE-UHFFFAOYSA-N
Physicochemical Property
logP
7.3145
Rotatable Bonds
13
Heavy Atom Count
43
Polar Areas
32.67
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4745652
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 259 nM
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