General Information of the Compound
Compound ID
CP0490622
Compound Name
N-[[4-[4-[4-[1-[(3-chlorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]phenyl]methyl]-N-methylprop-2-yn-1-amine
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Formula
C34H39ClN4O
Molecular Weight
555.166
Canonical SMILES
CN(CC#C)Cc1ccc(OCCCCN2CCN(CC2)c2cccc3n(Cc4cccc(Cl)c4)ccc23)cc1
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InChI
InChI=1S/C34H39ClN4O/c1-3-17-36(2)26-28-12-14-31(15-13-28)40-24-5-4-18-37-20-22-38(23-21-37)33-10-7-11-34-32(33)16-19-39(34)27-29-8-6-9-30(35)25-29/h1,6-16,19,25H,4-5,17-18,20-24,26-27H2,2H3
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InChIKey
CDAQXCQLAXCGRD-UHFFFAOYSA-N
Physicochemical Property
logP
6.3892
Rotatable Bonds
12
Heavy Atom Count
40
Polar Areas
23.88
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4786924
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 195 nM
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