General Information of the Compound
Compound ID
CP0490022
Compound Name
1-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-3-naphthalen-2-ylsulfonylurea
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Structure
Formula
C38H37N3O6S
Molecular Weight
663.796
Canonical SMILES
CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2ccc3ccccc3c2)cc1C
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InChI
InChI=1S/C38H37N3O6S/c1-4-46-34-29-12-8-9-13-30(29)35(47-5-2)33-31(34)23-41(36(33)42)32-17-14-25(20-24(32)3)22-38(18-19-38)39-37(43)40-48(44,45)28-16-15-26-10-6-7-11-27(26)21-28/h6-17,20-21H,4-5,18-19,22-23H2,1-3H3,(H2,39,40,43)
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InChIKey
IZGHIQSBSUJNDS-UHFFFAOYSA-N
Physicochemical Property
logP
7.02242
Rotatable Bonds
10
Heavy Atom Count
48
Polar Areas
114.04
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25019435
SID: 56363148
ChEMBL ID
CHEMBL1669007
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01534, Prostaglandin E2 receptor EP4 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  4
1
IC50 = 2.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 37 nM
   TI
   LI
   LO
   TS
3
Ki = 0.52 nM
   TI
   LI
   LO
   TS
4
Ki = 6.3 nM
   TI
   LI
   LO
   TS