General Information of the Compound
Compound ID
CP0489400
Compound Name
(3S,7E,8S,8aS)-2-acetyl-3-benzyl-7-benzylidene-8-(7-methoxy-1,3-benzodioxol-5-yl)-3,4,8,8a-tetrahydro-1H-pyrrolo[1,2-a]pyrazin-6-one
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Structure
Formula
C31H30N2O5
Molecular Weight
510.59
Canonical SMILES
COc1cc(cc2OCOc12)[C@@H]1[C@H]2CN([C@@H](Cc3ccccc3)CN2C(=O)\C1=C\c1ccccc1)C(C)=O
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InChI
InChI=1S/C31H30N2O5/c1-20(34)32-18-26-29(23-15-27(36-2)30-28(16-23)37-19-38-30)25(14-22-11-7-4-8-12-22)31(35)33(26)17-24(32)13-21-9-5-3-6-10-21/h3-12,14-16,24,26,29H,13,17-19H2,1-2H3/b25-14+/t24-,26+,29-/m0/s1
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InChIKey
VIDPPJILURFWHU-VZALMVKISA-N
Physicochemical Property
logP
4.2753
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
68.31
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156011377
ChEMBL ID
CHEMBL4637554
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000113 SW620/AD300 Homo sapiens (Human)  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS