General Information of the Compound
Compound ID
CP0489091
Compound Name
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]butanoylamino]-3-cyclohexylpropanoyl]amino]-3-cyclohexylpropanoyl]amino]-4-amino-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-2-methylpropanoyl]amino]-3-hydroxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[(1-amino-3-cyclohexyl-1-oxopropan-2-yl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide
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Structure
Formula
C80H143N25O17
Molecular Weight
1727.182
Canonical SMILES
CCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)NC(CC1CCCCC1)C(=O)NC(CC1CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC(CC1CCCCC1)C(N)=O
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InChI
InChI=1S/C80H143N25O17/c1-10-50(94-66(112)51(29-20-34-90-77(84)85)96-70(116)56(37-43(2)3)93-46(7)107)65(111)101-58(40-48-25-16-12-17-26-48)71(117)102-59(41-49-27-18-13-19-28-49)72(118)103-60(42-62(82)109)73(119)100-57(38-44(4)5)74(120)105-80(8,9)76(122)104-63(45(6)106)75(121)98-53(31-22-36-92-79(88)89)67(113)97-54(32-33-61(81)108)69(115)95-52(30-21-35-91-78(86)87)68(114)99-55(64(83)110)39-47-23-14-11-15-24-47/h43-45,47-60,63,106H,10-42H2,1-9H3,(H2,81,108)(H2,82,109)(H2,83,110)(H,93,107)(H,94,112)(H,95,115)(H,96,116)(H,97,113)(H,98,121)(H,99,114)(H,100,119)(H,101,111)(H,102,117)(H,103,118)(H,104,122)(H,105,120)(H4,84,85,90)(H4,86,87,91)(H4,88,89,92)/t45-,50?,51+,52+,53+,54+,55?,56+,57+,58?,59?,60+,63+/m1/s1
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InChIKey
CGPMHVFAWJATPJ-KDLULZTBSA-N
Physicochemical Property
logP
-3.07109
Rotatable Bonds
55
Heavy Atom Count
122
Polar Areas
713.5
Hydrogen Bond Donor Count
26
Hydrogen Bond Acceptor Count
20
Complexity
122

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137649292
ChEMBL ID
CHEMBL4076542
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01611, Neuropeptide Y receptor type 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 6.4 nM
   TI
   LI
   LO
   TS
2
IC50 = 17 nM
   TI
   LI
   LO
   TS