General Information of the Compound
Compound ID
CP0488653
Compound Name
1-(benzenesulfonyl)-4-[4-[3-(4-fluorophenoxy)propyl]piperazin-1-yl]indole
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Structure
Formula
C27H28FN3O3S
Molecular Weight
493.604
Canonical SMILES
Fc1ccc(OCCCN2CCN(CC2)c2cccc3n(ccc23)S(=O)(=O)c2ccccc2)cc1
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InChI
InChI=1S/C27H28FN3O3S/c28-22-10-12-23(13-11-22)34-21-5-15-29-17-19-30(20-18-29)26-8-4-9-27-25(26)14-16-31(27)35(32,33)24-6-2-1-3-7-24/h1-4,6-14,16H,5,15,17-21H2
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InChIKey
CCHZUMWJDOCSOK-UHFFFAOYSA-N
Physicochemical Property
logP
4.6085
Rotatable Bonds
8
Heavy Atom Count
35
Polar Areas
54.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71502632
SID: 163487350
ChEMBL ID
CHEMBL3409262
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 5.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 67 nM
   TI
   LI
   LO
   TS